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[Article Of Journal] 2014 JOE : Odontogenic Effect of a Fast-setting Pozzolan-based Pulp Capping Material   [VIEW : 5,890]
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Odontogenic Effect of a Fast-setting Pozzolan-based Pulp Capping Material

Su-Jung Park, DDS, PhD, Seok-Mo Heo, DDS, PhD, Sung-Ok Hong, DDS, MSD,Yun-Chan Hwang, DDS, PhD, Kwang-Won Lee, DDS, PhD,and Kyung-San Min, DDS, PhD


Introduction: Mineral trioxide aggregate (MTA) is widely used as a pulp capping material. Recently, a MTA-derived fast-setting pozzolan cement (Endocem; Maruchi, Wonju, Korea) was introduced in the endodontic field. Our aim in this study was to investigate the odontogenic effects of this cement in vitro and in vivo.
Methods: Human dental pulp cells (hDPCs) were cultured, and the effects of Endocem and a previously marketed MTA (ProRoot; Dentsply, Tulsa, OK) on biocompatibility were evaluated by assessing cell morphology and performing a cell viability test. Chemical
composition of each material was analyzed by energy-dispersive X-ray spectroscopic analysis. Odontoblastic
differentiation was analyzed by alkaline phosphatase activity and alizarin red S staining. The __EXPRESSION__ of odontogenic-related markers, namely dentin sialophosphoprotein, dentin matrix protein 1, and osteonectin, was evaluated by real-time polymerase chain reaction, Western blotting, and immunofluorescence analysis. Pinpoint pulp exposures were made on rat teeth and then capped with ProRoot or Endocem. After 4 weeks, reparative tertiary dentin formation and inflammatory responses were investigated histologically.
Results: The biocompatibility of Endocem was similar to that of ProRoot. Energy-dispersive X-ray spectroscopic
analysis showed that ProRoot and Endocem contained similar elemental constituents such as calcium, oxygen, and silicon. Alkaline phosphatase activity and mineralized nodule formation increased in ProRootand Endocem-treated cells compared with medium only–treated cells in the control group (P < .05). The __EXPRESSION__ of odontogenic-related markers was significantly higher in the ProRoot- and Endocem-treated groups than the control group (P < .05), but there was no significant difference in the __EXPRESSION__ of these markers between the 2 experimental groups (P > .05).
Four weeks after the pulp capping procedure, continuous tertiary dentin had formed directly underneath the capping materials and the pulp exposure area in all samples in the 2 treated groups. Furthermore, most specimens
either had no inflammation or minor pulpal inflammation.
Conclusions: Our results indicate that ProRoot and Endocem have similar biocompatibility and odontogenic effects. Therefore, Endocem is as effective a pulp capping material as ProRoot.

(J Endod 2014; in press)

Total 15
[Article Of Journal] 2015 JOE : A Randomized Controlled Study of the Use of ProRoot Mineral Trioxide Aggregate and Endocem as Direct Pulp Capping Materials
[Article Of Journal] 2014 IEJ : Evaluation of calcium-releasing and apatite-forming abilities of fast-setting calcium silicate-based endodontic materials
[Article Of Journal] 2014 RDE : Cytotoxicity of newly developed pozzolan cement and other root-end filling materials on human periodontal ligament cell
[Article Of Journal] 2014 JOE : Comparison of the Biological Properties of ProRoot MTA, Ortho MTA, and Endocem MTA Cements
[Article Of Journal] 2014 EJD : Coronectomy of a lower third molar in combination with vital pulp theraphy
[Article Of Journal] 2014 JOE : Effect of Mineral Trioxide Aggregate Surface Treatments on Morphology and Bond Strength to Composite Resin
*   [Article Of Journal] 2014 JOE : Odontogenic Effect of a Fast-setting Pozzolan-based Pulp Capping Material
[Article Of Journal] 2013 RDE : Washout resistance of faxt-setting pozzolan cement under various root canal irrigants
[Article Of Journal] 2013 JOE : Tooth Discoloration after the Use of New Pozzolan Cement(Endocem) and Mineral Trioxide Aggregate and the Effects of Internal Bleaching
[Article Of Journal] 2013 JOE : Biological Effects and Washout Resistance of a Newly Developed Fast-setting Pozzolan Cement
[Instruction For Use] ENDOSEAL Instruction For Use (August 15, 2013, Rev.1)
[Instruction For Use] ENDOCEM MTA / ENDOCEM Zr Instruction For Use (August 15, 2013, Rev.2)
[Instruction For Use] ENDOSEAL Instruction For Use (December 1, 2012, Rev.0)
[Instruction For Use] ENDOCEM MTA / ENDOCEM Zr Instruction For Use (December 1, 2012, Rev.1)
[Instruction For Use] ENDOCEM MTA Instruction For Use (November 7, 2011, Rev.0)